Use of mesenchymal stromal cells in hematopoietic stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Pediatric Hematopoietic Stem Cell Transplantation
The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...
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Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preve...
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Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...
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M esenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their adherent properties, immunephenotype and differentiation potential. MSCs display immunological properties that have been demonstrated both in vitro and in vivo, in animal models and in humans, although the exact mechanisms un...
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ژورنال
عنوان ژورنال: Journal of Hematopoietic Cell Transplantation
سال: 2016
ISSN: 2186-5612
DOI: 10.7889/hct.5.27